【Abstract】 Objective To study killing effects to rodents in large reservoir region, and provide scientific basis for rodent control.  Methods 0.1% sodium diphacinone was given indoor, and 0.005% Bromadiolone  outdoor in the Pingban reservoir region. 0.005% Bromadiolone baits were given in the outdoors of the Baise reservoir, Ertan reservoir and Changzhou reservoir region, while 0.0375% Racumin wheat baits was taken in the indoor and outdoor of Longtan reservoir region.  Results The killing rate was 83.89% in the Pingban reservoir, 83.40% in the Baise reservoir, 92.82% in the Ertan reservoir, 86.65% in the Longtan reservoir and 89.35% in the Changzhou reservoir region.  Conclusion Bromadiolone and Racumin had good killing effect on rodents in reservoir region, and the integrated control measure was taken to reduce effectively the rodent density.